A-68930 hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

A-68930 是一种有效、特异性、口服生物可利用的 D1 多巴胺受体激动剂，EC50 为 2.5 nM。

A-68930 is a potent, specific, orally bioavailable agonist of the D1 Dopamine receptor with EC50 of 2.5 nM; shows a much weaker agonist (EC50=3,920 nM) at the D2 dopamine receptor; demonstrates antidepressant and anorectic effects in animal models without stimulant effects.Heart Failure Discontinued.

A68930 hydrochloride (1 μM; 5-60 minutes; 16HBE14o- or NCI-H292 cells) significantly increases phosphorylation of cAMP response element binding (CREB) protein.A68930 hydrochloride (1 μM; 48 hours; NCI-H292 cells) induces MUC5AC mRNA expression and increases the mRNA data of MUC5AC and MUC5AC protein expression.A68930 hydrochloride (1 μM; 20 minutes; NCI-H292 cells) significantly increases intracellular cAMP levels. Western Blot Analysis Cell Line:16HBE14o- or NCI-H292 cells Concentration:1 μM Incubation Time:5~60 minutes Result:Significantly increased phosphorylation of CREB.RT-PCR Cell Line:NCI-H292 cells Concentration:1 μM Incubation Time:48 hours Result:Induced MUC5AC mRNA expression.Immunofluorescence Cell Line:NCI-H292 cells Concentration:1 μM Incubation Time:48 hours Result:The mRNA data of MUC5AC, MUC5AC protein expression were increased.

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A68930

GPCR/G Protein

Dopamine Receptor

Dopamine Receptor

Neurological Disease

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130465-39-3

307.77

C16H17NO3 · HCl

>98% (HPLC)

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C1C(OC(C2=C1C(=C(C=C2)O)O)CN)C3=CC=CC=C3.Cl

1H-2-Benzopyran-5,6-diol, 1-(aminomethyl)-3,4-dihydro-3-phenyl-, hydrochloride, (1R,3S)-rel- (9CI)

(-20℃)

With Ice Pack

≥ 2 years